In 1555 Pope Paul IV established the ghetto, with the papal bull “Cum nimis absurdum” (“It is truly absurd”). Nearly two thousand Jews were segregated in the unhealthy area roughly between what is now Via del Portico d’Ottavia, Piazza delle Cinque Scole and the River Tiber, which meant the ghetto was often flooded by the river. Their numbers would grow to five thousand by the 19th century. Not much remains of the district’s original crowded and multi-tiered lay-out. When it was finally opened up in 1870, a regeneration plan for the capital city led to it being completely gutted and rebuilt into four large, modern blocks. As far back as the 13th century, numerous groups of Jews had settled in the Sant’Angelo District, attracted by the large number of merchants and crafts in the area. The ghetto area was enlarged in several waves, so that by the 18th century it had five entry gates. Piazza Giudea was roughly between what are now Via del Portico d’Ottavia and Piazza delle Cinque Scole; this is where the main allowed business – money lending and second hand trade, especially cloth – took place. On Piazza delle Cinque Scole, approximately where number 37 is today, the building of the Cinque Scole once stood; it was demolished between 1908 and 1910.